SYK (AAH01645, 243 a.a. ~ 340 a.a) partial recombinant protein with GST tag. The sequence is HYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPG HRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREA
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Pathway
Adaptive Immune System; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; B Cell Receptor Signaling Pathway; BCR signaling pathway.
Citations
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