Anti-STXBP2 polyclonal antibody (DPABH-16699)

Rabbit Anti-Human STXBP2 (aa 310-524) polyclonal antibody for WB, ICC/IF Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Recombinant fragment, corresponding to a region within amino acids 310-524 of Human STXBP2 (AAH02869).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/500 - 1/3,000; ICC/IF:1/200.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
STXBP2; syntaxin binding protein 2; FHL5; UNC18B; Hunc18b; UNC18-2
Entrez Gene ID
UniProt ID

Product Background


Gene summary
STXBP2 (Syntaxin Binding Protein 2) is a Protein Coding gene. Diseases associated with STXBP2 include hemophagocytic lymphohistiocytosis, familial, 5 and hemophagocytic lymphohistiocytosis. Among its related pathways are Transcription_CREM signaling in testis and Insulin Signaling. GO annotations related to this gene include syntaxin-1 binding and syntaxin-3 binding. An important paralog of this gene is STXBP1. This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Antigen Description
Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells. Familial hemophagocytic lymphohistiocytosis 5 (FHL5) [MIM:613101]: A rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia. Note=The disease is caused by mutations affecting the gene represented in this entry. Syntaxin-binding protein 2 is a protein that in humans is encoded by the STXBP2 gene. 0The function about STXBP2 antigen include protein binding; syntaxin-1 binding; syntaxin-3 binding.
Pathway
Insulin Signaling.

Citations


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References


Zhao, XW; Gazendam, RP; et al. Defects in neutrophil granule mobilization and bactericidal activity in familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) syndrome caused by STXBP2/Munc18-2 mutations. BLOOD 122:109-111(2013).
Tang, YM; Xu, XJ; et al. Advances in Hemophagocytic Lymphohistiocytosis: Pathogenesis, Early Diagnosis/Differential Diagnosis, and Treatment. THESCIENTIFICWORLDJOURNAL 11:697-708(2011).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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