A region within synthetic peptide: LRLWQTVVGK TYGLWKCVLP EEDSGELAKP KIGFPETTEE ELEEIASENS, corresponding to C terminal amino acids 289-338 of Human Unrip
The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.
Pathway
Disease; Loss of Function of SMAD2/3 in Cancer; Loss of Function of TGFBR1 in Cancer; RNA transport
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