Plays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.
Pathway
Adaptive Immune System, organism-specific biosystem; Antigen Activates B Cell Receptor Leading to Generation of Second Messengers, organism-specific biosystem; Elevation of cytosolic Ca2+ levels, organism-specific biosystem; Hemostasis, organism-specific biosystem; Immune System, organism-specific biosystem; Platelet calcium homeostasis, organism-specific biosystem; Platelet homeostasis, organism-specific biosystem;
Citations
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