Specifications
Immunogen
Recombinant full length mature Human Stromal interaction molecule 1 corresponding to amino acids 23-685 with a proprietary tag (AAH21300).
Applications
Application Notes
WB: 1/500 - 1/1000; IHC-P: 5 μg/ml; ICC/IF: 10 μg/ml;
Target
Alternative Names
STIM1; stromal interaction molecule 1; D11S4896E; GOK; STIM1L;
Product Background
Antigen Description
Plays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.
Pathway
Adaptive Immune System, organism-specific biosystem; Antigen Activates B Cell Receptor Leading to Generation of Second Messengers, organism-specific biosystem; Elevation of cytosolic Ca2+ levels, organism-specific biosystem; Hemostasis, organism-specific biosystem; Immune System, organism-specific biosystem; Platelet calcium homeostasis, organism-specific biosystem; Platelet homeostasis, organism-specific biosystem;
Citations
Publication ()
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COA
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