Plays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.
Pathway
Adaptive Immune System, organism-specific biosystem; Antigen Activates B Cell Receptor Leading to Generation of Second Messengers, organism-specific biosystem; Elevation of cytosolic Ca2+ levels, organism-specific biosystem; Hemostasis, organism-specific biosystem; Immune System, organism-specific biosystem; Platelet calcium homeostasis, organism-specific biosystem; Platelet homeostasis, organism-specific biosystem;
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Clark, AJ; Diamond, M; et al. Calicum microdomains form within neutrophils at the neutrophil-tumor cell synapse: role in antibody-dependent target cell apoptosis. CANCER IMMUNOLOGY IMMUNOTHERAPY 59:149-159(2010).
Wenning, AS; Neblung, K; et al. TRP expression pattern and the functional importance of TRPC3 in primary human T-cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1813:412-423(2011).
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COA
Certificate of Analysis
