Anti-STAT1 monoclonal antibody, clone 2252DU37.3.2

Antibody Isotype

IgG1

Clone

2252DU37.3.2

Species Reactivity

Human

Conjugate

Application Notes

WB: 1:1000

Alternative Names

STAT1; Signal transducer and activator of transcription 1-alpha/beta; Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84

Entrez Gene ID

UniProt ID

Antigen Description

Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine-and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.

Pathway

AGE/RAGE pathway; Adipogenesis; Antiviral mechanism by IFN-stimulated genes; B Cell Receptor Signaling Pathway; BDNF signaling pathway; CXCR4-mediated signaling events; Chemokine signaling pathway; Cytokine Signaling in Immune system;