Anti-ST14 polyclonal antibody (DPAB-DC424)

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to residues surrounding amino acids 629 of rat St14.
Conjugate
Unconjugated

Applications


Application Notes
WB: 0.5-4 μg/mL. & The optimal working dilution should be determined by the end user.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
ST14; suppression of tumorigenicity 14 (colon carcinoma); MT-SP1; matriptase; membrane-type serine protease; suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ST14 (Suppression Of Tumorigenicity 14) is a Protein Coding gene. Diseases associated with ST14 include ichthyosis, congenital, autosomal recessive 11 and ichthyosis-hypotrichosis syndrome. Among its related pathways are MicroRNAs in cancer and TNF Signaling (sino). GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is ACR. The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.
Antigen Description
regulates the cell-substratum adhesion by controlling the intestinal epithelial turnover [RGD, Feb 2006]Ichthyosis, congenital, autosomal recessive 11 (ARCI11) [MIM:602400]: A form of autosomal recessive congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs. Note=The disease is caused by mutations affecting the gene represented in this entry. The function about ST14 antigen include serine-type endopeptidase activity; serine-type peptidase activity.
Pathway
MicroRNAs in cancer.

Citations


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References


Mori, M; Ishikawa, G; et al. The cytotrophoblast layer of human chorionic villi becomes thinner but maintains its structural integrity during gestation. BIOLOGY OF REPRODUCTION 76:164-172(2007).
Kim, SB; Lee, D; et al. Soluble Epithin/PRSS14 Secreted from Cancer Cells Contains Active Angiogenic Potential. MOLECULES AND CELLS 29:617-623(2010).

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