General Notes
This product (Catalog No. DPABH-03788) is a rabbit-derived polyclonal antibody raised against human SPRED2, targeting the amino acid region 122–214 of the protein. This antibody exhibits cross-reactivity with Human SPRED2 from mouse and rat. It has been affinity purified by Protein A. SPRED2 is a member of the SPRED family of proteins that modulate GFR signaling by inhibiting the Ras-MAPK cascade (PMID: 17094949). SPRED family members are characterized by an N-terminal Enabled/VASP homology 1 domain (EVH1), a central c-Kit binding domain (KBD) and a C-terminal Sprouty-related domain (SPR) (PMID: 17691106). Three mammalian SPREDs (SPRED1-3) have been described. In adult tissues, SPRED2 is expressed ubiquitously, but most highly expressed in glandular epithelia (PMID: 15580519; 17691106). Reduced expression level of SPRED2 has been reported in human hepatocellular carcinoma (HCC), suggesting SPRED2 may play a role in tumorgenesis (PMID: 16652141). Gene disruption of SPRED2 causes dwarfism (PMID: 15946934).
DPABH-03788 is suitable for use in Western blot (WB) (1:1,000–1:6,000), IHC (1:50–1:500), IF/ICC (1:50–1:500) applications.
DPABH-03788 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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