antigen: NQKKLAMLNA QKAGHGKSKG YNRCPVAPPH QGLHPIHQRH ITMPTSVPQQ QVFGLAEPKR KSSLFWHTFN RLT, corresponding to amino acids 576-648 of Human SPATA13 Isoforms 1,2,3 and 5 (Q96N96). This is partially absent in Isoform 4.
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
Pathway
Regulation of CDC42 activity;
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