SMURF1 (NP_065162, 165 a.a. ~ 268 a.a) partial recombinant protein with GST tag. The sequence is DSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTP QNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP
This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010]
Pathway
Adaptive Immune System; Proteasome degradation; BMP receptor signaling; Class I MHC mediated antigen processing &.
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