Anti-SMTN monoclonal antibody (DMABT-H15427)

Mouse anti-Chicken SMTN monoclonal antibody for WB, IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
S5B
Species Reactivity
Chicken, Human
Immunogen
Native purified chicken SMTN.
Conjugate
Unconjugated

Applications


Application Notes
Immunohistochemistry (1:5-1:10) & The optimal working dilution should be determined by the end user.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
SMTN; smoothelin; FLJ35168; FLJ35365; FLJ35620; FLJ38597
Entrez Gene ID
UniProt ID

Product Background


Gene summary
SMTN (Smoothelin) is a Protein Coding gene. Diseases associated with SMTN include retroperitoneal cancer and atrophy of prostate. GO annotations related to this gene include actin binding and structural constituent of muscle. An important paralog of this gene is SMTNL2. This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12. 3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
Antigen Description
Structural protein of the cytoskeleton. Smoothelin is a protein that in humans is encoded by the SMTN gene. 0The function about SMTN antigen include actin binding; structural constituent of muscle.

Citations


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References


Karuppagounder, SS; Xu, H; et al. Translocation of amyloid precursor protein C-terminal fragment(s) to the nucleus precedes neuronal death due to thiamine deficiency-induced mild impairment of oxidative metabolism. NEUROCHEMICAL RESEARCH 33:1365-1372(2008).
Yang, GA; Meng, Y; et al. Neuronal MCP-1 Mediates Microglia Recruitment and Neurodegeneration Induced by the Mild Impairment of Oxidative Metabolism. BRAIN PATHOLOGY 21:279-297(2011).

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