SLD5 or GINS4 is a member of the GINS complex which is involved in initiation of replication and unwinding of DNA. It is highly conserved amongst eukaryotes. The GINS complex in yeast associates with DNA polymerase epsilon and stimulates its catalytic activity. It also interacts with Cdc45 and the MCM2-7 complex to activate the eukaryotic minichromosome maintenance helicase.
Pathway
Cell Cycle, Mitotic, organism-specific biosystem; DNA Replication, organism-specific biosystem; DNA strand elongation, organism-specific biosystem; S Phase, organism-specific biosystem; Synthesis of DNA, organism-specific biosystem; Unwinding of DNA, orga.
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