This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described.
Pathway
Calcium Regulation in the Cardiac Cell; Calcium signaling pathway;Hemostasis; Platelet calcium homeostasis; Platelet homeostasis; Protein digestion and absorption; Protein digestion and absorption; Reduction of cytosolic Ca++ levels; SLC-mediated transmembrane transport; Sodium/Calcium exchangers; Transmembrane transport of small molecules;
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