Anti-SLC44A1 monoclonal antibody [R-PE] (CABT-46885MH)

Mouse anti-Human SLC44A1 monoclonal antibody for FC

Additional Formats Available

Specifications


Host Species
Mouse
Antibody Isotype
IgG2b
Clone
VIM-15b
Species Reactivity
Human
Immunogen
MV4-11 acute monocyte leukaemia cells.
Conjugate
R-PE

Applications


Application Notes
Flow Cyt: Neat - 1/10;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
SLC44A1; solute carrier family 44 (choline transporter), member 1; CD92; CTL1; CDW92; CHTL1
Entrez Gene ID
UniProt ID
Q8WWI5

Product Background


Pathway
Choline metabolism in cancer; Glycerophospholipid biosynthesis; Metabolism; Metabolism of lipids and lipoproteins; Phospholipid metabolism; SLC-mediated transmembrane transport; Synthesis of PC; Transmembrane transport of small molecules;

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Mouse IgG2b Isotype Control [R-PE] DAGIC980 FC Mouse PDF Inquiry

References


Choline-related-inherited metabolic diseasesA mini review

JOURNAL OF INHERITED METABOLIC DISEASE

Authors: Wortmann, Saskia B.; Mayr, Johannes A.

In humans, the important water soluble, vitamin-like nutrient choline, is taken up with the diet or recycled in the liver. Deficiencies of choline have only been reported in experimental situations or total parenteral nutrition. Currently, no recommended dietary allowances are published; only an adequate daily intake is defined. Choline is involved in three main physiological processes: structural integrity and lipid-derived signaling for cell membranes, cholinergic neurotransmission, and methylation. Choline is gaining increasing public attention due to studies reporting a relation of low choline levels to subclinical organ dysfunction (nonalcoholic fatty liver or muscle damage), stunting, and neural tube defects. Furthermore, positive effects on memory and a lowering of cardiovascular risks and inflammatory markers have been proposed. On the other hand, dietary choline has been associated with increased atherosclerosis in mice. This mini review will provide a summary of the biochemical pathways, in which choline is involved and their respective inborn errors of metabolism (caused by mutations in SLC5A7, CHAT, SLC44A1, CHKB, PCYT1A, CEPT1, CAD; DHODH, UMPS, FMO3, DMGDH, and GNMT). The broad phenotypic spectrum ranging from malodor, intellectual disability, to epilepsy, anemia, or congenital myasthenic syndrome is presented, highlighting the central role of choline within human metabolism.

EWSR1-PATZ1 gene fusion may define a new glioneuronal tumor entity

BRAIN PATHOLOGY

Authors: Siegfried, Aurore; Rousseau, Audrey; Maurage, Claude-Alain; Pericart, Sarah; Nicaise, Yvan; Escudie, Frederic; Grand, David; Delrieul, Alix; Gomez-Brouchet, Anne; Le Guellec, Sophie; Franchet, Camille; Boetto, Sergio; Vinchon, Matthieu; Sol, Jean-Christophe; Roux, Franck-Emmanuel; Rigau, Valerie; Bertozzi, Anne-Isabelle; Jones, David T. W.; Figarella-Branger, Dominique; Uro-Coste, Emmanuelle

We investigated the challenging diagnostic case of a ventricular cystic glioneuronal tumor with papillary features, by RNA sequencing using the Illumina TruSight RNA Fusion panel. We did not retrieve the SLC44A1-PRKCA fusion gene specific for papillary glioneuronal tumor, but an EWSR1-PATZ1 fusion transcript. RT-PCR followed by Sanger sequencing confirmed the EWSR1-PATZ1 fusion. It matched with canonic EWSR1 fusion oncogene, juxtaposing the entire N-terminal transcriptional activation domain of EWSR1 gene and the C-terminal DNA binding domain of a transcription factor gene, PATZ1. PATZ1 protein belongs to the BTB-ZF (broad-complex, tramtrack and bric-a-brac -zinc finger) family. It directly regulates Pou5f1 and Nanog and is essential to maintaining stemness by inhibiting neural differentiation. EWSR1-PATZ1 fusion is a rare event in tumors: it was only reported in six round cell sarcomas and in three gliomas of three exclusively molecular studies. The first reported glioma was a BRAF(V600E) negative ganglioglioma, the second a BRAF(V600E) negative glioneuronal tumor, not otherwise specified and the third, very recently reported, a high grade glioma, not otherwise specified. In our study, forty BRAF(V600E) negative gangliogliomas were screened by FISH using EWSR1 break-apart probes. We performed methylation profiling for the index case and for seven out of the ten FISH positive cases. The index case clustered apart from other pediatric low grade glioneuronal entities, and specifically from the well-defined ganglioglioma methylation group. An additional pediatric intraventricular ganglioglioma clustered slightly more closely with ganglioglioma, but showed differences from the main ganglioglioma group and similarities with the index case. Both cases harbored copy number variations at the PATZ1 locus. EWSR1-PATZ1 gene fusion might define a new type of glioneuronal tumors, distinct from gangliogliomas.

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