Anti-SLC10A1 monoclonal antibody, clone FQS9707

Antibody Isotype

IgG

Clone

FQS9707

Conjugate

Application Notes

WB: 1:1,000 - 10,000; ICC: 1:100 - 250

Alternative Names

SLC10A1; solute carrier family20(sodium/bile acid cotransporter family), member 1; sodium/bile acid cotransporter; NTCP; growth-inhibiting protein 29; Na(+)/bile acid cotransporter; sodium/taurocholate cotransporter; solute carrier family20member 1; Na(+)

Entrez Gene ID

UniProt ID

Antigen Description

SLC10A1 belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis.

Pathway

Bile acid and bile salt metabolism, organism-specific biosystem; Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Recycling of bile acids and salts, organism-specific biosystem;