Anti-SIX5 monoclonal antibody (DCABH-13449) Made to order

Rabbit anti-Human SIX5 monoclonal antibody for WB, ELISA Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human SIX5 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
SIX5; SIX homeobox 5; DMAHP, sine oculis homeobox (Drosophila) homolog 5 , sine oculis homeobox homolog 5 (Drosophila); homeobox protein SIX5; sine oculis homeobox homolog 5; DM locus-associated homeodomain protein
Entrez Gene ID
UniProt ID

Product Background


Gene summary
SIX5 (SIX Homeobox 5) is a Protein Coding gene. Diseases associated with SIX5 include branchiootorenal syndrome 2 and branchiootorenal syndrome. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is SIX2. The protein encoded by this gene is a homeodomain-containing transcription factor that appears to function in the regulation of organogenesis. This gene is located downstream of the dystrophia myotonica-protein kinase gene. Mutations in this gene are a cause of branchiootorenal syndrome type 2.
Antigen Description
The protein encoded by this gene is a homeodomain-containing transcription factor that appears to function in the regulation of organogenesis. This gene is located downstream of the dystrophia myotonica-protein kinase gene. Mutations in this gene are a cause of branchiootorenal syndrome type 2. Branchiootorenal syndrome 2 (BOR2) [MIM:610896]: A syndrome characterized by branchial cleft fistulas or cysts, sensorineural and/or conductive hearing loss, pre-auricular pits, structural defects of the outer, middle or inner ear, and renal malformations. Note=The disease is caused by mutations affecting the gene represented in this entry. Homeobox protein SIX5 is a protein that in humans is encoded by the SIX5 gene. 0The function about SIX5 antigen include protein binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity.

Citations


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References


Man, NT; Pham, YCN; et al. Nuclear localization of the myotonic dystrophy-associated Six5 protein using a new panel of monoclonal antibodies. JOURNAL OF THE NEUROLOGICAL SCIENCES 199:S5-S5(2002).
Ohto, H; Takizawa, T; et al. Tissue and developmental distribution of Six family gene products. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY 42:141-148(1998).

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