Specifications
Species Reactivity
Rat; Human; Monkey
Immunogen
Nuclear protein isolated from rat liver nuclei.
Applications
Application Notes
IHC-P: 1 μg/ml; WB: 5 μg/ml; ICC/IF: 5 μg/ml; Flow Cyt: 1-2μg/106 cells.
Target
Alternative Names
SF3A2; splicing factor 3a, subunit 2; splicing factor 3A subunit 2; splicing factor 3a, subunit 2, 66kDa;
Product Background
Antigen Description
Subunit of the splicing factor SF3A required for A complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the E complex.
Pathway
Spliceosome, organism-specific biosystem; Spliceosome, conserved biosystem; Spliceosome, U2-snRNP, organism-specific biosystem; mRNA processing, organism-specific biosystem.
Citations
Publication ()
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COA
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