Anti-SETDB1 (aa 2-100) polyclonal antibody

Species Reactivity

Human

Immunogen

SETDB1 (NP_036564, 2 a.a. ~ 100 a.a) partial recombinant protein with GST tag. The sequence is SSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQL AELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFY

Conjugate

Alternative Names

SETDB1; SET domain, bifurcated 1; ESET; KG1T; KMT1E; TDRD21; H3-K9-HMTase4; histone-lysine N-methyltransferase SETDB1; H3-K9-HMTase 4; tudor domain containing 21; lysine N-methyltransferase 1E; histone H3-K9 methyltransferase 4; ERG-associated protein wit

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011]

Pathway

Lysine degradation;