Anti-SERPINE1 monoclonal antibody, clone 353927

Antibody Isotype

IgG1

Clone

353927

Species Reactivity

Human

Immunogen

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Serpin E1/PAI-1. Met1-Pro402 Accession Number P05121

Conjugate

Application Notes

Western Blot: 1 μg/mL; ELISA Capture: 2-8 μg/mL; ELISA Detection: 0.1-0.4 μg/mL
We recommend the following for sandwich ELISA (Capture - Detection):
DCABY-4032 - DPABY-367

Alternative Names

SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; PAI; PAI1; PAI-1; PLANH1; plasminogen activator inhibitor 1; serpin E1; endothelial plasminogen activator inhibitor; serine (or cysteine) proteinase i

Entrez Gene ID

UniProt ID

Antigen Description

The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins.

Pathway

Adipogenesis; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Blood Clotting Cascade; Chagas disease (American trypanosomiasis); Circadian Clock; Complement and Coagulation Cascades; Complement and coagulation cascades; Direct p53 effectors;