Rabbit Anti-Human SEPT4 Polyclonal Antibody (DPABH-25970)
Rabbit Anti-Human SEPT4 Polyclonal Antibody for IHC, WB
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Recombinant Protein, antigen sequence: YDDDLEFRPPSRPQSSDNQQYFCAPAPLSPSARPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKS
IHC: 1:20 - 1:50
WB: 0.4 µg/ml
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Immunohistochemical staining of human cerebral cortex shows high expression.
Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11
Lane 2: Human cell line RT-4
Lane 3: Human cell line U-251MG sp
Lane 4: Human plasma (IgG/HSA depleted)
Lane 5: Human liver tissue
Lane 6: Human tonsil tissue
SEPT4; septin 4; H5; ARTS; MART; SEP4
SEPT4 (Septin 4) is a Protein Coding gene. Diseases associated with SEPT4 include artemis deficiency and parkinson disease, late-onset. Among its related pathways are ERK Signaling and Actin Nucleation by ARP-WASP Complex. GO annotations related to this gene include GTP binding and structural molecule activity. An important paralog of this gene is SEPT6. This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer.
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli. Septin-4 is a protein that in humans is encoded by the SEPT4 gene. This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. The protein encoded by this gene is thought to be part of a complex involved in cytokinesis. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. The function about SEPT4 antigen include GTP binding; GTPase activity; protein binding; structural molecule activity.
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Gottfried, Y; Rotem, A; et al. The pro-apoptotic ARTS/Sept4 protein is significantly reduced in post-mortem brains from schizophrenic patients. SCHIZOPHRENIA RESEARCH 96:257-266(2007).
Sugino, Y; Ichioka, K; et al. Septins as Diagnostic Markers for a Subset of Human Asthenozoospermia. JOURNAL OF UROLOGY 180:2706-2709(2008).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.