Synthetic peptide corresponding to a region within C-terminal amino acids 520-569 (SIYSSERSVL QSINPAEPHK ECPNPKPDKA PLQKVSLAPN SRYYLSCPME) of Human Semaphorin 7a (NP_003603).
Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
Pathway
Axon guidance; Axon guidance; Other semaphorin interactions;
Citations
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