Anti-SELS monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human SELS is used for rabbit immunization.

Conjugate

Alternative Names

SELS; selenoprotein S; VCP-interacting membrane protein; VIMP; ADO15; SBBI8; SEPS1; AD-015; MGC2553; MGC104346;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3 UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Pathway

HRD1/SEL1 ERAD complex, organism-specific biosystem; HRD1/SEL1 ERAD complex, conserved biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem; Protein processing in endoplasmic reticulum, conserved biosystem; Selenium Metabolism and Selenoproteins, organism-specific biosystem; Selenium Pathway, organism-specific biosystem;