Anti-SEC23A monoclonal antibody (DCABH-6625) Knockout Validated

Rabbit anti-Human SEC23A monoclonal antibody for WB, FC

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Clone
FQS24381(C)
Species Reactivity
Human
Immunogen
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human SEC23 aa 300-400 (Cysteine residue). The exact sequence is proprietary.Database link: Q15436
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/10000 - 1/50000; Flow Cyt: 1/10 - 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
SEC23A; Sec23 homolog A (S. cerevisiae); Sec23 (S. cerevisiae) homolog A; protein transport protein Sec23A; SEC23-related protein A; CLSD
Entrez Gene ID
UniProt ID

Product Background


Gene summary
SEC23A (Sec23 Homolog A, Coat Complex II Component) is a Protein Coding gene. Diseases associated with SEC23A include craniolenticulosutural dysplasia and cole-carpenter syndrome. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. An important paralog of this gene is SEC23B. The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking.
Antigen Description
Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex. Craniolenticulosutural dysplasia (CLSD) [MIM:607812]: Autosomal recessive syndrome characterized by late-closing fontanels, sutural cataracts, facial dysmorphisms and skeletal defects. Note=The disease is caused by mutations affecting the gene represented in this entry. Sec23 homolog A (S. cerevisiae), also known as SEC23A, is a protein which in humans is encoded by the SEC23A gene. The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It contains a gelsolin domain. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking.
Pathway
Adaptive Immune System, organism-specific biosystem; Antigen Presentation: Folding, assembly and peptide loading of class I MHC, organism-specific biosystem; Asparagine N-linked glycosylation, organism-specific biosystem; COPII (Coat Protein 2) Mediated Vesicle Transport, organism-specific biosystem; COPII complex, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem.

Citations


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