Anti-SCNN1A monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human SCNN1A is used for rabbit immunization.

Conjugate

Alternative Names

SCNN1A; sodium channel, non-voltage-gated 1 alpha subunit; SCNN1, sodium channel, non voltage gated 1 alpha , sodium channel, nonvoltage gated 1 alpha; amiloride-sensitive sodium channel subunit alpha; ENaCalpha; alpha-ENaC; alpha-NaCH; alpha ENaC-2; epit

Entrez Gene ID

UniProt ID

Antigen Description

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Pathway

Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem; Taste transduction, organism-specific biosystem; Taste transduction, conserved biosystem.