Anti-SCAP (aa 53-83) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide within Human SCAP aa 53-83 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: Q12770

Conjugate

Application Notes

WB: 1/100 - 1/500; IHC-P: 1/10 - 1/50; Flow Cyt: 1/10 - 1/50.

Alternative Names

SCAP; SREBF chaperone; sterol regulatory element-binding protein cleavage-activating protein; KIAA0199; SREBP cleavage activating protein; SREBP cleavage-activating protein; sterol regulatory element binding protein cleavage-activating protein;

Entrez Gene ID

UniProt ID

Antigen Description

Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway.