This product (Catalog No. DPABH-10079) is a rabbit-derived polyclonal antibody raised against human SAV1, targeting the amino acid region 208–383 of the protein. This antibody exhibits cross-reactivity with Human SAV1 from mouse and rat. It has been affinity purified by Protein A. The Salvador family WW domain-containing 1 (SAV1, also known as WW45) is a human homologue of Salvador that contains two protein-protein interaction modules known as WW domains and acts as a scaffolding protein (PMID: 28618450). SAV1 belongs to the core kinase components of Hippo signalling pathway for efficient MST1/2 activation. SAV1 represses the growth of colorectal cancer cells by inactivating Akt-mTOR signalling in a YAP-dependent manner (PMID: 29063833, 22185343). DPABH-10079 is suitable for use in Western blot (WB) (1:500–1:2,000), IHC (1:50–1:500), IF/ICC (1:50–1:500) applications. DPABH-10079 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
Target
Alternative Names
45 kDa WW domain protein; hWW45; Protein salvador homolog 1; SAV
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