Anti-Rubella virus Capsid protein Monoclonal antibody (DMABT-51537MR)

Mouse Anti-Rubella virus Capsid protein Monoclonal antibody for IHC, ELISA, FC, HA, IB, IP, WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
2D22
Species Reactivity
Rubella virus
Immunogen
Purified Rubella virus, strain HPV72
Conjugate
Unconjugated

Target


Alternative Names
Coat protein; german measles; german measles capsid protein; p110; rubella capsid; Structural polyprotein

Product Background


Antigen Description
Rubella virus is the only member of the Rubrivirus genus of the Togavirus family. Unlike most Togaviruses it is NOT arthropod borne, but is acquired via the respiratory route. It causes German measles ( a mild contagious eruptive disease, capable of producing congenital defects in infants born to mothers infected during the first three months of pregnancy). Rubella virus is an enveloped positive-strand RNA virus. The genome encodes two open reading frames (ORFs): the 5-proximal ORF encodes viral nonstructural proteins (NSP) that are responsible for viral genome replication, while the 3-proximal ORF encodes three virion structural proteins (SP), the capsid protein (CP), and the two envelope glycoproteins, E2 and E1. During virus assembly, the capsid interacts with genomic RNA to form nucleocapsids. The rubella virus (RV) structural proteins: capsid, E2, andF2are synthesized as a polyprotein precursor. The signal peptide that initiates translocation of E2 into the lumen of the endoplasmic reticulum remains attached to the carboxy terminus of the capsid protein after cleavage by signal peptidase.

Citations


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References


HOBMAN, TC; SETO, NOL; et al. EXPRESSION OF SOLUBLE FORMS OF RUBELLA-VIRUS GLYCOPROTEINS IN MAMMALIAN-CELLS. VIRUS RESEARCH 31:277-289(1994).
LewensohnFuchs, I; Ljungman, P; et al. Loss of seroreactivity against human papillomavirus (HPV) in bone marrow transplant recipients. BONE MARROW TRANSPLANTATION 18:333-337(1996).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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