Anti-RNASEL polyclonal antibody (DPABT-H80751)

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Mouse
Conjugate
Unconjugated

Target


Alternative Names
RNASEL; ribonuclease L (2, 5-oligoisoadenylate synthetase-dependent); 2-5A-dependent ribonuclease; RNase L; ribonuclease 4; 2-5A-dependent RNase
Entrez Gene ID
UniProt ID

Product Background


Gene summary
RNASEL (Ribonuclease L) is a Protein Coding gene. Diseases associated with RNASEL include prostate cancer 1 and chronic fatigue syndrome. Among its related pathways are Immune System and Interferon gamma signaling. GO annotations related to this gene include RNA binding and protein kinase activity. An important paralog of this gene is KIDINS220. This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele.
Antigen Description
Prostate cancer, hereditary, 1 (HPC1) [MIM:601518]: A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Ribonuclease L or RNase L (for latent), known sometimes as ribonuclease 4 or 2-5 oligoadenylate synthetase-dependent ribonuclease — is an interferon (IFN)-induced ribonuclease which, upon activation, destroys all RNA within the cell (both cellular and viral). RNase L is an enzyme that in humans is encoded by the RNASEL gene. 0The function about RNASEL antigen include ATP binding; RNA binding; endonuclease activity; endoribonuclease activity, producing 5-phosphomonoesters; hydrolase activity; metal ion binding; nuclease activity; nucleotide binding; protein kinase activity; rRNA binding; ribonuclease activity; transferase activity, transferring phosphorus-containing groups.
Pathway
Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem; Influenza A, organism-specific biosystem; Influenza A, conserved biosystem; Senescence and Autophagy, organism-specific biosystem.

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References


Hohn, O; Krause, H; et al. Lack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients. RETROVIROLOGY 6:-(2009).
Arnold, RS; Makarova, NV; et al. XMRV Infection in Patients With Prostate Cancer: Novel Serologic Assay and Correlation With PCR and FISH. UROLOGY 75:755-761(2010).

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