Anti-ABCA3 monoclonal antibody (CABT-35910MR)

Mouse anti-Rat ABCA3 monoclonal antibody for EM, ICC, IHC-Fr, WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
4D0
Species Reactivity
Mouse, Rat
Immunogen
Purified rat lamellar body membranes.
Conjugate
Unconjugated

Applications


Application Notes
IHC-P: 10μg/ml; Electron Microscopy:WB: 1/1000
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
ABCA3; ATP-binding cassette, subfamily A (ABC1), member 3; ATP-binding cassette sub-family A member 3; ABC 3; ABC C; ABC C transporter
Entrez Gene ID

Product Background


Gene summary
ABCA3 (ATP Binding Cassette Subfamily A Member 3) is a Protein Coding gene. Diseases associated with ABCA3 include surfactant metabolism dysfunction, pulmonary, 3 and abca3-related pulmonary surfactant metabolism dysfunction. Among its related pathways are Transport to the Golgi and subsequent modification and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCA4. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The full transporter encoded by this gene may be involved in development of resistance to xenobiotics and engulfment during programmed cell death.
Antigen Description
This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. Pulmonary surfactant metabolism dysfunction 3 (SMDP3) [MIM:610921]: A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Note=The disease is caused by mutations affecting the gene represented in this entry. ATP-binding cassette sub-family A member 3 is a protein that in humans is encoded by the ABCA3 gene.
Pathway
ABC transporters, organism-specific biosystem; ABC transporters, conserved biosystem.

Citations


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References


Gerelsaikhan, T; Chen, XL; et al. Secretagogues of lung surfactant increase annexin A7 localization with ABCA3 in alveolar type II cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1813:2017-2025(2011).
Yamano, G; Funahashi, H; et al. ABCA3 is a lamellar body membrane protein in human lung alveolar type II cells. FEBS LETTERS 508:221-225(2001).

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