Synthetic peptide corresponding to a region within C terminal amino acids 617-666 (LGAKDLLHAP EEGPFTFPNG EAVEHGEESK DRTIMLMGVS SQKISLRLKR) of Human Rasgrp1 (NP_005730).
Conjugate
Unconjugated
Applications
Application Notes
WB: 1 μg/ml.
Target
Alternative Names
RASGRP1; RAS guanyl releasing protein 1 (calcium and DAG-regulated); RAS guanyl-releasing protein 1; CalDAG GEFII; RASGRP; ras activator RasGRP; RAS guanyl nucleotide-releasing protein 1; calcium and DAG-regulated guanine nucleotide exchange factor II; gu
RasGRP1 is a Ras-specific exchange factor, which is activated by T-cell receptor (TCR) and promotes TCR-dependent positive selection of thymocytes. RasGRP1 is highly expressed on most T lymphocytic leukemias and is a common site of proviral insertion in retrovirus-induced murine T-cell lymphomas.
Pathway
Activation of RAS in B Cells; Adaptive Immune System; Downstream Signaling Events Of B Cell Receptor (BCR); Effects of PIP2 hydrolysis; G alpha (q) signalling events; GPCR downstream signaling; Hemostasis
Citations
Publication ()
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