Anti-RAD51C (full length) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Full length protein corresponding to Human Rad51C aa 1-376.Sequence: MRGKTFRFEMQRDLVSFPLSPAVRVKLVSAGFQTAEELLEVKPSELSKEV GISKAEALETLQIIRRECLTNKPRYAGTSESHKKCTALELLEQEHTQGFI ITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGG VAGEAVFIDTEGSFMVDRVVDLATACIQHLQLI

Conjugate

Application Notes

WB: 1 μg/ml.

Alternative Names

RAD51C; RAD51 homolog C (S. cerevisiae); RAD51 (S. cerevisiae) homolog C; DNA repair protein RAD51 homolog 3; RAD51L2; R51H3; RAD51-like protein 2; yeast RAD51 homolog 3; RAD51 homolog C, isoform 1; FANCO; BROVCA3; MGC104277;

Entrez Gene ID

UniProt ID

Antigen Description

Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Participates in branch migration and Holliday junction resolution and thus is important for processing HR intermediates late in the DNA repair process. Also has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis.

Pathway

Factors involved in megakaryocyte development and platelet production; Fanconi anemia pathway; Hemostasis; Homologous recombination; Meiosis;