Specifications
Species Reactivity
Mouse; Rat; Dog; Human
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 300 - 400 of Human RUNX2.
Applications
Application Notes
WB: 1 μg/ml.
Target
Alternative Names
RUNX2; runt-related transcription factor 2; CBFA1, CCD, CCD1; AML3; PEBP2A1; PEBP2aA1; CBF-alpha-1; PEA2-alpha A; PEBP2-alpha A; oncogene AML-3; acute myeloid leukemia 3 protein; SL3-3 enhancer factor 1 alpha A subunit; osteoblast-specific transcription f
Product Background
Antigen Description
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5-PYGPYGGT-3, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters (By similarity). Inhibits MYST4-dependent transcriptional activation.
Pathway
Androgen Receptor Signaling Pathway; Endochondral Ossification; FGF signaling pathway; Gene Expression; Generic Transcription Pathway; Notch-mediated HES/HEY network; Regulation of nuclear SMAD2/3 signaling
Citations
Publication ()
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COA
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