Anti-RPL21 polyclonal antibody (DPAB-DC2732)

Mouse anti-Human RPL21 (aa 2-85) polyclonal antibody for WB, ELISA

Specifications


Host Species
Mouse
Species Reactivity
Human, Mouse
Immunogen
RPL21 (NP_000973, 2 a.a. ~ 85 a.a) partial recombinant protein with GST tag. The sequence is TNTKGKRRGTRYMFSRPFRKHGVVPLATYMRIYKKGDIVDIKGMGTVQKGMPHKCYHGKTGRVYNVTQHAVGIVVNKQVKGKIL
Conjugate
Unconjugated

Target


Alternative Names
RPL21; ribosomal protein L21; L21; 60S ribosomal protein L21
Entrez Gene ID
UniProt ID

Product Background


Gene summary
RPL21 (Ribosomal Protein L21) is a Protein Coding gene. Diseases associated with RPL21 include hypotrichosis 12 and hypotrichosis simplex. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L21E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Antigen Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L21E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Hypotrichosis 12 (HYPT12) [MIM:615885]: A form of hypotrichosis, a condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The extent of scalp and body hair involvement can be very variable, within as well as between families. HYPT12 patients have normal scalp hair density at birth. Hair loss begins during the first 6 months of life and gradually progresses to nearly complete loss of scalp hair. The remaining hairs grow slowly and are thin, sparse, dry, and fragile. Body hair, axillary and pubic hair, eyebrows and eyelashes are also sparse or absent. Note=The disease is caused by mutations affecting the gene represented in this entry. 60S ribosomal protein L21 is a protein that in humans is encoded by the RPL21 gene. 0The function about RPL21 antigen include RNA binding; poly(A) RNA binding; structural constituent of ribosome.
Pathway
Cap-dependent Translation Initiation; Disease; Eukaryotic Translation Initiation; Formation of a pool of free 4S subunits.

Citations


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References


SUGANO, S; KIM, DW; et al. USE OF AN EPITOPE-TAGGED CDNA LIBRARY TO ISOLATE CDNAS ENCODING PROTEINS WITH NUCLEAR-LOCALIZATION POTENTIAL. GENE 120:227-233(1992).
Mikulik, K; Suchan, P; et al. Changes in ribosome function induced by protein kinase associated with ribosomes of Streptomyces collinus producing kirromycin. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 289:434-443(2001).

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