Anti-ROR alpha + beta + gamma monoclonal antibody, clone I4036

Antibody Isotype

IgG2a

Clone

I4036

Species Reactivity

Rat; Human

Immunogen

Recombinant fragment, corresponding to amino acids 136-236 of Human ROR alpha + beta + gamma

Conjugate

Application Notes

WB: 1 μg/ml; ELISA: 0.2 μg/ml;

Alternative Names

RORA; RAR-related orphan receptor A; nuclear receptor ROR-alpha; NR1F1; ROR1; ROR2; ROR3; RZRA; ROR-alpha; nuclear receptor RZR-alpha; transcription factor RZR-alpha; retinoid-related orphan receptor alpha; nuclear receptor subfamily 1 group F member 1; t

Entrez Gene ID

UniProt ID

Antigen Description

ROR alpha, beta and gamma are members of the NR1 subfamily of nuclear hormone receptors. They can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. ROR alpha binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence. ROR beta is required for normal postnatal development of rod and cone photoreceptor cells.

Pathway

Adipogenesis, organism-specific biosystem; BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Circadian Repression of Expression by REV-ERBA, organism-specific biosystem; Circadian rhythm - mammal, organism-specific biosystem; Circadian rhythm - mammal, conserved biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem;