Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
Recombinant fragment within Human ROCK1 aa 107-411. The exact sequence is proprietary.Database link: Q13464
Applications
Application Notes
WB: 1/500 - 1/3000;
Target
Alternative Names
ROCK1; Rho-associated, coiled-coil containing protein kinase 1; rho-associated protein kinase 1; p160ROCK; p160-ROCK; Rho kinase; p160 ROCK-1; renal carcinoma antigen NY-REN-35; rho-associated, coiled-coil-containing protein kinase 1; rho-associated, coil
Product Background
Antigen Description
Phosphorylates and activates DAPK3, which then regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. Required for centromere positioning and centromere-dependent exit from mitosis. Necessary for apoptotic membrane blebbing.
Pathway
Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem;
Citations
Publication ()
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COA
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