Anti-RNPS1 (aa 158-239) polyclonal antibody

Species Reactivity

Human

Immunogen

RNPS1 (NP_006702, 158 a.a. ~ 239 a.a) partial recombinant protein with GST tag. The sequence is PKPTKVHIGRLTRNVTKDHIMEIFSTYGKIKMIDMPVERMHPHLSKGYAYVEFENPDEAE KALKHMDGGQIDGQEITATAVL

Conjugate

Alternative Names

RNPS1; RNA binding protein S1, serine-rich domain; E5.1; RNA-binding protein with serine-rich domain 1; SR protein; SR-related protein LDC2; RNA-binding protein S1, serine-rich domain;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Several transcript variants encoding different isoforms have been found for this gene.

Pathway

Cleavage of Growing Transcript in the Termination Region; Exon junction complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Processing of Capped Intron-Containing Pre-mRNA.