Anti-RNASEH2C (aa 87-116) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide within Human RNase H2 subunit C aa 87-116 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: Q8TDP1

Conjugate

Application Notes

Flow Cyt: 1/10 - 1/50; WB: 1/1000;

Alternative Names

RNASEH2C; ribonuclease H2, subunit C; AGS3; AYP1; ribonuclease H2 subunit C; RNase H2 subunit C; RNase H1 small subunit; ribonuclease HI subunit C; aicardi-Goutieres syndrome 3 protein;

Entrez Gene ID

UniProt ID

Antigen Description

The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C (Ribonuclease H2 subunit C). Ribonuclease H2 subunit C is the non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. It participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Ribonuclease H2 subunit C also mediates the excision of single ribonucleotides from DNA:RNA duplexes.

Pathway

DNA replication;