Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human BLAP75 aa 600 to the C-terminus (Cysteine residue). The exact sequence is proprietary.Database link: Q9H9A7
Applications
Application Notes
WB: 1/1000 - 1/10000; ICC/IF: 1/50 - 1/100.
Target
Alternative Names
RMI1; RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae); C9orf76, chromosome 9 open reading frame 76; recQ-mediated genome instability protein 1; BLAP75; BLM Associated Polypeptide; 75 kDa; FLJ12888; BLM-associated protein 75 kDa; BLM-ass
Product Background
Antigen Description
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
Pathway
Blooms syndrome complex, organism-specific biosystem; Fanconi anemia pathway, organism-specific biosystem; Fanconi anemia pathway, conserved biosystem.
Citations
Publication ()
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COA
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