The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified.
Pathway
Calcium Regulation in the Cardiac Cell; G alpha (i) signalling events; GPCR downstream signaling; Myometrial Relaxation and Contraction Pathways; Signal Transduction; Signaling by GPCR;
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