Synthetic peptide corresponding to an internal region of Human RFWD3.
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/500 - 1/1000.
Target
Alternative Names
RFWD3; ring finger and WD repeat domain 3; E3 ubiquitin-protein ligase RFWD3; FLJ10520; RNF201; RING finger protein 201; RING finger and WD repeat domain-containing protein 3;
E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53.
Citations
Publication ()
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