Anti-REV1 (aa 1097-1194) polyclonal antibody

Species Reactivity

Human

Immunogen

REV1L (NP_057400, 1097 a.a. ~ 1194 a.a) partial recombinant protein with GST tag. The sequence is SPAKTLPGACGSPQKLIDGFLKHEGPPAEKPLEELSASTSGVPGLSSLQSDPAGCVRPPA PNLAGAVEFNDVKTLLREWITTISDPMEEDILQVVKYC

Conjugate

Alternative Names

REV1; REV1, polymerase (DNA directed); REV1L; DNA repair protein REV1; AIBP80; REV1- like; REV1 homolog; alpha integrin-binding protein 80; rev1-like terminal deoxycytidyl transferase;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found.

Pathway

DNA Damage Bypass; Fanconi anemia pathway; Translesion synthesis by HREV1;