General Notes
This product (Catalog No. DPABH-03710) is a rabbit-derived polyclonal antibody raised against human RCC1, targeting the amino acid region 1–421 of the protein. This antibody exhibits cross-reactivity with Human RCC1 from mouse and rat. It has been affinity purified by Protein A. CHC1, also named as RCC1, promotes the exchange of ran-bound gdp by gtp. It is involved in the regulation of onset of chromosome condensation in the S-phase. Phosphorylation of RCC1 on serines located in or near its nuclear localization signal activates RCC1 to generate RanGTP on mitotic chromosomes, which is required for spindle assembly and chromosome segregation.
DPABH-03710 is suitable for use in Western blot (WB) (1:1,000–1:5,000), IP (0.5-4.0 μg for 1.0-3.0 mg of total protein lysate), IHC (1:50–1:500), IF/ICC (1:20–1:200) applications.
DPABH-03710 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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