Anti-RAN monoclonal antibody Made to order

Name: Anti-RAN monoclonal antibody
SKU: DCABH-13173
Rating: 5 (1 reviews)

Rabbit anti-Human RAN monoclonal antibody for WB, ELISA

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COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human RAN is used for rabbit immunization.

Conjugate

Unconjugated

Target

Alternative Names

RAN; RAN, member RAS oncogene family; GTP-binding nuclear protein Ran; ARA24; Gsp1; TC4; RanGTPase; GTPase Ran; OK/SW-cl.81; ras-like protein TC4; member RAS oncogene family; ras-related nuclear protein; guanosine triphosphatase Ran; androgen receptor-ass

Entrez Gene ID

5901

UniProt ID

B4DV51

Product Background

Antigen Description

RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedys disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedys disease.

Pathway

Androgen Receptor Signaling Pathway, organism-specific biosystem; Aurora A signaling, organism-specific biosystem; Canonical NF-kappaB pathway, organism-specific biosystem; Disease, organism-specific biosystem; Export of Viral Ribonucleoproteins from Nucleus, organism-specific biosystem; FoxO family signaling, organism-specific biosystem; Gene Expression, organism-specific biosystem;

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

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Customer Reviews

References

Governance by depositors, bank runs and ambiguity aversion

RESEARCH IN INTERNATIONAL BUSINESS AND FINANCE

Authors: Guillemin, Francois

Abstract

We investigate the theoretical relationship between ambiguity aversion and the decision to withdraw early from a deposit contract. We first document and define the concepts to illustrate our results. Then we extend the theoretical framework of Gorton (1985) to implement a model of maxmin expected utility to match the ambiguity aversion hypothesis. We observe that the most ambiguous depositors are more likely to mistakenly withdraw their deposits, reducing bank stability and leading to inefficient bank runs. We also show higher ambiguity levels negatively impact bank equity levels.

Changes in water fluxes partition related to the replacement of native dry forests by crops in the Dry Chaco

JOURNAL OF ARID ENVIRONMENTS

Authors: Rodriguez, Paula; Gimenez, Raul; Nosetto, Marcelo D.; Jobbagy, Esteban G.; Magliano, Patricio N.

Abstract

Land-use change has been the strongest driver of vegetation cover change in the world. In the South American Dry Chaco (similar to 1 M km(2); PPT/ET0 < 0.65), native dry forests are experiencing high deforestation rates that tend to continue in the coming years. Here, we used a hydrological model (Hydrus 1-D) to analyze changes in the water balance triggered by the replacement of dry forests by annual rainfed summer crops. We found that transpiration represented the main water vapour flux in both vegetation covers (59 and 48% of annual rainfall in dry forest and cropland, respectively), followed by evaporation (31 and 30%, respectively) and interception (11 and 9%, respectively). Runoff was five times higher in the cropland compared to the dry forest (10 vs. 2%; p < 0.01). Deep drainage was a negligible water flux in dry forests but it represented 4% of annual rainfall in croplands (p < 0.01), reaching values of zero and 130 mm year(-1) for dry and wet years, respectively. Our results highlight the key role of vegetation cover controlling ecosystem water fluxes in the Dry Chaco. More generally, we suggest that the expansion of dryland cultivation can modify the regional water balance and threaten the primary production of ecosystems in the long run.