Anti-RALBP1 monoclonal antibody, clone 7D7

Antibody Isotype

IgG1

Clone

7D7

Species Reactivity

Human; African green monkey

Immunogen

Recombinant full length protein corresponding to Human RALBP1 aa 1-655. (NP_006779) produced in HEK293T cell.Sequence: MTECFLPPTSSPSEHRRVEHGSGLTRTPSSEEISPTKFPGLYRTGEPSPP HDILHEPPDVVSDDEKDHGKKKGKFKKKEKRTEGYAAFQEDSSGDEAESP SKMKRSKGIHVFKKPSFSKKKEKDFKIKEKPKEE

Conjugate

Application Notes

WB: 1/1000; IP: 2μg;

Alternative Names

RALBP1; ralA binding protein 1; ralA-binding protein 1; RIP; RIP1; RLIP76; DNP-SG ATPase; ral-interacting protein 1; 76 kDa Ral-interacting protein; dinitrophenyl S-glutathione ATPase; RLIP1;

Entrez Gene ID

UniProt ID

Antigen Description

Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.

Pathway

EGFR1 Signaling Pathway, organism-specific biosystem; Pancreatic cancer, organism-specific biosystem; Pancreatic cancer, conserved biosystem; Pathways in cancer, organism-specific biosystem; Regulation of CDC42 activity, organism-specific biosystem; Regulation of RAC1 activity, organism-specific biosystem; Rho GTPase cycle, organism-specific biosystem;