Anti-RAB10 monoclonal antibody, clone FQS24353

Antibody Isotype

IgG

Clone

FQS24353

Species Reactivity

Mouse; Rat; Human

Immunogen

Recombinant fragment within Human RAB10. The exact sequence is proprietary.Database link: P61026

Conjugate

Application Notes

WB, FC, ELISA(Det)
Recommended working dilution:
WB: 1/1000 - 1/5000; FC: 1/10 - 1/100;
We also recommend the following for sandwich ELISA (Capture - Detection):
DCABH-13141P - DCABH-7255

Alternative Names

RAB10; RAB10, member RAS oncogene family; ras-related protein Rab-10; ras related GTP binding protein; GTP-binding protein RAB10; ras-related GTP-binding protein;

Entrez Gene ID

UniProt ID

Antigen Description

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the basolateral membrane. Moreover, may play a role in the basolateral recycling pathway and in phagosome maturation. According to PubMed:23263280, may play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion.