Anti-Pyrraline monoclonal antibody (DMAB12742)

Mouse anti-Pyrraline monoclonal antibody for IHC, ELISA Datasheet

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Host Species
Antibody Isotype
Species Reactivity
Human, Mouse, Rat
Pyrraline conjugated with HSA.


Application Notes
Immunohistochemistry (2 μg/mL); ELISA (0.1-0.5 μg/mL) & The optimal working dilution should be determined by the end user.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.


Alternative Names
Pyrraline; Anti-Pyrraline MAb; Mouse Anti-Pyrraline Monoclonal Antibody; Pyrraline; Anti-Pyrraline MAb, Biotin-conjugated; Mouse Anti-Pyrraline Monoclonal Antibody, Biotin-conjugated

Product Background

Antigen Description
Pyrraline is one of the major Maillard compounds resulting from the reaction of glucose and amino coumpounds at slightly acidic pH. Using anti-pyrraline antibody, pyrraline was detected in sclerosed glomeruli from diabetic and normal old kidneys as well as in renal arteries with arteriosclerosis. Futhermore, it was detected in neurofibrillary tangles and senile plaques in brain tissue from patients with Alzheimer's disease.


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Odani, H; Shinzato, T; et al. First evidence for accumulation of protein-bound and protein-free pyrraline in human uremic plasma by mass spectrometry. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 224:237-241(1996).
Suzuki, D; Miyata, T; et al. Immunohistochemical evidence for an increased oxidative stress and carbonyl modification of proteins in diabetic glomerular lesions. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 10:822-832(1999).

Custom Antibody Labeling

We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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