Anti-Pyrraline monoclonal antibody (DMAB12742)
Mouse anti-Pyrraline monoclonal antibody for IHC, ELISA
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Human, Mouse, Rat
Pyrraline conjugated with HSA.
Immunohistochemistry (2 μg/mL); ELISA (0.1-0.5 μg/mL) & The optimal working dilution should be determined by the end user.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Pyrraline; Anti-Pyrraline MAb; Mouse Anti-Pyrraline Monoclonal Antibody; Pyrraline; Anti-Pyrraline MAb, Biotin-conjugated; Mouse Anti-Pyrraline Monoclonal Antibody, Biotin-conjugated
Pyrraline is one of the major Maillard compounds resulting from the reaction of glucose and amino coumpounds at slightly acidic pH. Using anti-pyrraline antibody, pyrraline was detected in sclerosed glomeruli from diabetic and normal old kidneys as well as in renal arteries with arteriosclerosis. Futhermore, it was detected in neurofibrillary tangles and senile plaques in brain tissue from patients with Alzheimer's disease.
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Odani, H; Shinzato, T; et al. First evidence for accumulation of protein-bound and protein-free pyrraline in human uremic plasma by mass spectrometry. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 224:237-241(1996).
Miyata, S; Liu, BP; et al. Accumulation of pyrraline-modified albumin in phagocytes due to reduced degradation by lysosomal enzymes. JOURNAL OF BIOLOGICAL CHEMISTRY 272:4037-4042(1997).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.