Antigen Description
Protein kinase C (PKC) is a family of serine-threonine kinases that regulate a broad spectrum of cellular functions. The family is composed of nine genes that express structurally related phospholipid-dependent kinases with distinct means of regulation and tissue distribution. Based on their structures and sensitivities to Ca2+ and diacylglycerol (DAG), they have been classified into conventional PKCs (Alpha, Beta, and Gamma), novel PKCs (Sigma, Epsilon, Eta, and Phi), and atypical PKCs (Zeta and Lambda/Lota). PKC r is a member of the cPKC subfamily which is activated by Ca2+ and diacylglycerol in the presence of hosphatidylserine. Physiologically, PKC r is activated by a mechanism coupled with receptor-mediated breakdown of inositol phospholipid as other cPKC isotypes. PKC r is expressed solely in the brain and spinal cord and its localization is restricted to neurons. Within the brain, PKC r is the most abundant in the cerebellum, hippocampus and cerebral cortex, where the existence of neuronal plasticity has been demonstrated.
Pathway
African trypanosomiasis; Aldosterone-regulated sodium reabsorption; Amoebiasis; Ca-dependent events; CaM pathway; Calcium Regulation in the Cardiac Cell; Calcium signaling pathway; Calmodulin induced events; DAG and IP3 signaling; Dopaminergic synapse; Downstream signal transduction; Downstream signaling of activated FGFR; EGFR interacts with phospholipase C-gamma; EGFR1 Signaling Pathway
COA
Publication 
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