PEG3 (Paternally Expressed 3) is a Protein Coding gene. Diseases associated with PEG3 include glioma and undifferentiated embryonal sarcoma of the liver. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway. GO annotations related to this gene include nucleic acid binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms.
Peg3 encodes a C2H2 type zinc finger protein that is implicated in regulating core body temperature, feeding behavior and obesity in mice. The Peg3 gene transcript encodes a zinc finger protein of 1,572 amino acids. Peg3 is expressed in early somites, branchial arches, and other mesodermal tissues, as well as in the hypothalamus. PEG3 induces apoptosis in cooperation with SIAH1A and acts as a mediator between TP53/p53 and BAX in a neuronal death pathway that is activated by DNA damage. PEG3 acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B. PEG3 also possesses a tumor suppressing activity in glioma cells. GENE FUNCTION Kim et al. (1997) reported that the PEG3 gene, like other genes within the region on 19q to which it maps, also encodes a Kruppel-type ZNF protein, but one that is distinguished from other ZNF gene products by the fact that it carries 2 novel proline-rich motifs. The mouse and partial human PEG3 gene sequences showed a high level of conservation, despite that fact that 1 of the 2 proline-rich repeats is absent from the human gene. Kim et al. (1997) found that the human gene is expressed at highest levels in ovary and placenta; mouse Peg3, by contrast, is transcribed at highest levels in the adult brain. Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells. Paternally-expressed gene 3 protein is a protein that in humans is encoded by the Peg3 gene. Peg3 is an imprinted gene expressed exclusively from the paternal allele and plays important roles in controlling fetal growth rates and nurturing behaviors as has potential roles in mammalian reproduction. PEG3 is a transcription factor that binds to DNA [11-13] via the sequence motif AGTnnCnnnTGGCT, which it binds to using multiple Kruppel-like factors. It also regulate the expression of Pgm2l1 through the binding of the motif. 0The function about PEG3 antigen include metal ion binding; nucleic acid binding; zinc ion binding.