Specifications
Immunogen
B7-DC transfected RAW264.7 cells.
Applications
Application Notes
Neat - 1/5 Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors.
Target
Alternative Names
Pdcd1lg2; programmed cell death 1 ligand 2; Btdc; B7-DC; PD-L2; F730015O22Rik; programmed cell death 1 ligand 2; PD-1 ligand 2; PDCD1 ligand 2; butyrophilin B7-DC; butyrophilin-like protein; programmed death ligand 2
Product Background
Antigen Description
CD273 has been identified as a ligand for PD-1(CD279), along with another B7 family member B7-H1 (CD274). Studies suggest that both CD273 and B7-H1 co-stimulate or inhibit T cell proliferation and cytokine production.
Pathway
Adaptive Immune System; Cell adhesion molecules (CAMs); Costimulation by the CD28 family; Immune System; PD-1 signaling
Citations
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Shi, M; Roemer, MGM; et al. Expression of Programmed Cell Death 1 Ligand 2 (PD-L2) Is a Distinguishing Feature of Primary Mediastinal (Thymic) Large B-cell Lymphoma and Associated With PDCD1LG2 Copy Gain. AMERICAN JOURNAL OF SURGICAL PATHOLOGY 38:1715-1723(2014).
Ansell, SM; Lesokhin, AM; et al. PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma. NEW ENGLAND JOURNAL OF MEDICINE 372:311-319(2015).
COA
Certificate of Analysis
