Anti-PVR monoclonal antibody (CAB-9447MH)

Mouse anti-PVR monoclonal antibody for ELISA, WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
Mouse IgG1.
Clone
CBSB035CB.
Species Reactivity
N/A
Immunogen
Recombinant human PVR protein
Conjugate
Unconjugated

Target


Alternative Names
PVR; poliovirus receptor; PVS; CD155; HVED; Necl 5
Entrez Gene ID
UniProt ID
P15151

Product Background


Gene summary
PVR (Poliovirus Receptor) is a Protein Coding gene. Diseases associated with PVR include poliomyelitis and paralytic poliomyelitis. Among its related pathways are Immune System and Cell junction organization. GO annotations related to this gene include receptor activity and virus receptor activity. An important paralog of this gene is NECTIN3. The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.
Antigen Description
CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein.May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport (PubMed:2538245). Acts as a receptor for pseudorabies virus (PubMed:9616127). Is prevented to reach cell surface upon infection by human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells (PubMed:15640804). CD155 (cluster of differentiation 155) also known as the poliovirus receptor is a protein that in humans is encoded by the PVR gene. CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155s normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. The role of CD155 in the immune system is unclear, though it may be involved in intestinal humoral immune responses. Subsequent data has also suggested that CD155 may also be used to positively select MHC-independent T cells in the thymus.
Pathway
Adaptive Immune System, organism-specific biosystem; Adherens junctions interactions, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-cell junction organization, organism-specific biosystem.

Citations


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References


Endresz, V; Burian, K; et al. Optimization of DNA immunization against human cytomegalovirus. VACCINE 19:3972-3980(2001).
HEIDENKUMMER, HP; KAMPIK, A; et al. IMMUNOHISTOCHEMICAL LOCALIZATION OF EPIDERMAL GROWTH-FACTOR RECEPTOR IN A HUMAN EPIRETINAL MEMBRANE. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 229:492-496(1991).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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